Effectiveness of transfusion of whole blood derived platelets compared to apheresis platelets

Objective To compare the clinical effectiveness of whole blood derived platelets and apheresis platelets in children with hematological diseases.Methods Children were divided into two groups: apheresis platelet group(463 children) and whole-blood-derived platelet group(155 children).The platelet corrected count increment(CCI),percentage platelet recovery(PPR),the incidence rate of post-transfusion refractoriness to platelets(PTR) and adverse reaction were observed and assayed at 24,48 and 72hours after transfusion.Results In the apheresis platelet group,CCI and PPR at 24,48,and 72 hours after transfusion were significantly higher(P0.01),which were 18.9% and 15.4%,14.1% and 33.4%,27.8% and 25.0%,respectively.The incidence rate of PTR and adverse reaction in apheresis group were 10.58% and 3.02%,respectively,which were lower than those of whole-blood-derived platelet group.Both groups could achieve hemostasis quickly.Conclusion Apheresis platelets have higher CCI,and low incidence rate of PTR and less adverse transfusion reaction,compared to whole blood derived platelet concentrates.