Expression of IL- 1βmRNA in Rats of Cerebral Infarction and Immune Interventional Mechanism after the Combination of Medicine and Acupuncture

Objective: To observe IL- 1β mRNA expression of the rats with cerebral infarction,explore the immune interventional effect by Chinese medicine and electro- acupuncture treatment. Methods: Healthy Wistar rats weighing 280 ~ 350 g were randomly divided into five groups: normal control group( A group),model group( B group),Chinese medicine group( C group),electro- acupuncture group( D group) and Chinese medicine and electro- acupuncture group( E group),each group with six rats. C ~ E groups according to the treatment time were divided into four groups secondly,respectively they were 2 d and 4 d,6 d and 8d groups after the treatment. We prepared the rats of cerebral infarction by blocking on the right side of the brain artery of rats;observe the expression of IL- 1β mRNA of rats after treatment. Results: IL- 1β mRNA of group B was significantly higher than that in group A( P 0. 01); Compared with group B,IL- 1βmRNA expressions of group C and E were declined obviously after treatment,and the difference was significant( P 0. 05); After four days of treatment,IL- 1β mRNA expression of each treatment group was significantly decreased. Group E was significant,and maintain for the treatment lasted six days and eight days,compared with group C and D( P 0. 05).Conclusion: IL- 1β mRNA expression of group B significantly increases,and the effect of electro- acupuncture in the treatment of early stage is remarkable,and the combination of acupuncture with medicine can maintain the treatment effect in the late,then control inflammatory damage and promote brain tissue repairment,as the extension of treatment time,this advantage is more apparent.