Clinical analysis of TP and MVP regimens in the treatment of 72 patients with non-small cell lung cancer

Objective To evaluate the efficacy and toxicity of combination chemotherapy of Mitomycin plus Vindesine and Cisplatin,Paclitaxel plus Cisplatin in the treatment of advanced non-small cell lung cancer.Methods Seventy-two patients with non-small cell lung cancer were enrolled.Thirty-seven patients received MVP(Mitomycin 6~8 mg/m~2,day 1,Vindesine 2~3 mg/m~2,day 1,8 and Cisplatin 70~80 mg/m~2 day 1).Thirty-five patients received TP(Paclitaxel 170~180 mg/m~2,day 1 and Cisplatin 70~80 mg/m~2,day 1).It lasted for tow or three cycles.Results The objective response rate was 27.0% in the MVP arm and 42.9% in the TP arm.The main side effects were myelosuppression,nausea,vomiting on the MVP arm and myelosuppression,nausea,vomiting,shed on the TP arm.Conclusions There is not significant difference in response rate between the MVP and TP regimens.The side effects are tolerable.