Study on Reproduction Toxicity Influence of Nucleoside Analogs to Pregnant Rats

The goal of this experiment is determine the female rats in the first 6-15 days of pregnancy tail intravenous injection of nucleoside analogues tested products on the mother,embryo-fetal development and the impact of teratogeny.After mating,the pregnant and healthy rats were randomly divided into high,medium,low and the control group.Then examination when pregnancy 20 days,recording each animal pregnant uterine weight,corpus luteum,the number of implantation,early and late absorption fetal,the numbers of live births and stillbirths;live births aberdeen judgment gender,weight,the appearance of malformations and conduct inspection variability.Through experimentation,observation of nucleoside analogues tested products low-dose group of pregnant rats the size of the increase in body weight,early and late fetal absorption few,waterloo average number of live births,placental weight were compared with the control group had no significant differences between the high dose group of pregnant rats the size of the increase in body weight,litter number of stillbirths,the stillbirth of a few mice compared with the control group had significant differences.Note dose 200 mg·(kg·d)-1(effective dose in rats 40 times) will have significant toxicity in pregnant rats.The maternal toxicity,but no embryo red role and teratogenic effect on fetal development without adverse reaction.Therefore when use the drugs,its recommend dose is 100 mg·(kg·d)-1.