The toxic effects of Alibendol during perinatal period in rats

OBJECTIVE:To identify the toxic effects of Alibendol on the maternal rat in late trimester of pregnancy,the growth and development,and the abilities of learning and reproduction of the offsprings. METHODS:SD pregnant rats were given Alibendol orally from gestational day 15 to weaning day 21. The experimental groups received 50,100 and 200 mg/(kg·d) of Alibendol.The growth,development and reproductive capacity of pregnant rats and offsprings were recorded. RESULTS:There were no obviouse toxic effects on F0 rats.For the body weight of fetal rats(F1),there was a significant increase in low-dose group compared with control group at birth, day 4 after birth and mature male (P0.05). However,a significant difference of fetal rats in ear path opening in low-dose group and pain threshold time in meddle-dose group compared with control group (P0.05) were observed too. But there was no dose-effect relationship. There were no differences between treated groups and control group in other indexes. CONCLUSION:Among the dose range used,Alibendol was safe to reproductive capability of female rats and growth of fetal rats.