Efficacy of Noninvasive Positive Pressure Ventilation for Chronic Obstructive Pulmonary Disease with Respiratory Failure

Objective To explore the therapeutic effects of noninvasive positive pressure ventilation(NPPV) for chronic obstructive pulmonary disease(COPD) combined with respiratory failure.Methods Eight patients with stable COPD and respiratory failure underwent bi-level positive airway pressure(Bi-PAP) by nasal or facial mask.The arterial blood gases analysis and pulmonary ventilation functions were observed before the treatment and two months after the treatment.Results The difference of PaCO2(61.837±18.214 vs 40.013±1.768 mm Hg),PaO2(44.125±11.679 vs 76.000±9.970) and SaO2(%)(72.125±12.789 vs 91.750±3.410) were significantly(P0.05) before and after the treatment.There were also significant difference in the pulmonary functions of FEV1:(18.00±4.36 vs 34.67±8.96),FEV1/FVC:(43.67±2.52 vs 55.00±4.58) before and after the treatment(P0.05).Conclusion NPPV can improve the pulmonary ventilation function and hypoxic,decrease the plasma level of carbon dioxide(CO2) in patients with stable COPD and respiratory failure.