Experimental study on inhibition of corneal neovascularization with recombinant human secretory endostatin

Objective:To study the inhibition effects of recombinant human secretory endostatin on corneal neovascularization of rabbits.Methods:Stitching cornea was used to induce the formation of corneal neovascularization in rabbits.On the first day after manipulation,recombinant endostatin and nor-mal saline were separatively injected into subconjunctival tissues to observe the growth of corneal neovas-cularization and histopathological changes.Results:Endostatin treatment group showed shorter elongations and smaller areas of new blood vessels than normal saline group.Moreover,fewer neovascularities,plasmo-cytes and fibroblasts in endostatin treatment group were observed under the light microscope(P0.05).Con-clusion:The results indicated that the subconjunctival injection of recombinant endostatin could inhibit the growth of corneal neovascularization,which will provide a new method for the prevention and treatment of corneal neovascularization in clinic.