A Controlled Study of Mirtazapine and Amitrptyline in Somatization

OBJECTIVE:To compare curative effects, adverse reactions and the safety of mirtazapine and amitriptyline in the treatment of obsession . METHODS:60 patients with somatization disorder were randomly divided into study group (n=30, took mirtazapine) and control group (n=30, took amitriptyline).Curative effects were evaluated with SCL-90 before and at the end of treatment ,at the 2nd, fourth and eighth week of treatment,respectively. Adverse reactions were evaluated with TESS. RESULTS: Curative effects of mirtazapine and amitriptyline were 93.3% and 90% respectively, there was no significant difference(P0.05). Adverse reactions of the former were significantly fewer than that of the latter (P0.01), and it also had good tolerance. CONCLUSION: Curative effect of mirtazapine is correspond to that of amitriptyline, but adverse reactions are fewer. Mirtazapine is a safe and effective new antidepressant.