Effects of Methylphenidate on Event Related Potential in Children with Attention Deficit Hyperactivity Disorder

Objective To investigate the effect of methylphenidate on event related potential(ERP) in children with attention deficit hyperactivity disorder(ADHD).Methods Thirty-two children with ADHD(ADHD group)were treated for oral using methylphenidate and observed for 2 hours,scale for the assessment of methylphenidate were evaluated with the P300 ERP in Go/Nogo task.Thirty healthy children(healthy control group) were controls,to compare the differences of ERP main components.Results The latency[(355.16±17.04) ms] and amplitude[(5.88±1.72) μV] of Go-P3 in ADHD group after treatment were significantly shorter and higher than before treatment[(366.66±19.32) ms and(4.82±2.14) μV,Pa0.05],but longer and lower than those in healthy control group[(333.70±23.57) ms and(7.19±1.87) μV,Pa0.05].The amplitude [(6.13±1.68) μV] of Nogo-P3 in ADHD group after treatment were significantly higher than before treatment[(5.04±1.76) μV,P0.05],but lower than that in healthy control group[(8.32±2.03) μV,P0.05].Conclusion Methylphenidate can improve the attention and inhibitive executive functions in children with ADHD.