Protective effect of dexmedetomidine on rats with acute renal injury induced by lipopolysaccharide

Objective To observe the effects of dexmedetomidine on rats with acute renal injury induced by lipopolysaccharide. Methods 18 adult male SD rats were randomly divided into 3 groups: control group( group C,n = 6),LPS group( group L,n = 6),dexmedetomidine group( group D,n = 6). In group C and group L,the rats were infused with saline and lipopolysaccharide( 5 mg / kg,iv) respectively. In group D,after the infusion of lipopolysaccharide( 5 mg /kg,iv),the rats were firstly infused the loaded dose of dexmedetomidine( 7 μg /kg),and then infused at a rate of5 μg /( kg·h). 6 h later,3 m L blood was collected for measuring TNF-α,IL-1β,Scr and BUN. Histological analysis of the kidneys was performed. Results The levels of TNF-α,IL-1β,Scr and BUN in group L and group D were higher than those of group C( P 0. 05),and the above indexes in group D was lower than that of group L( P 0. 05). Histological changes: the kidney of the group D showed lessened injury. Conclusion Dexmedetomidine can alleviate the inflammation induced by lipopolysaccharide,improve the renal function and thus protect the kidneys from these injuries.