Distribution of Connexin 37 gene C1019T polymorphism in Han population in Shanxi province

Objective To investigate the distribution of the gap junction protein related to cardiovascular disease Connexin 37(Cx 37) gene C1019T polymorphism in the Han population in Shanxi province. Methods The polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique was used to examine Cx37 gene C1019T polymorphism of 116 unrelated healthy persons.χ~2 test was used to compare the genotype and allele frequencies of Han population with those of other ethnic populations. Results The allele frequencies of Cx 37 gene C1019T were as follows: C=68.5%,T=31.5%.The genotype frequencies were as follows:C/C=63.8%,C/T=30.2%,T/T=6.0%;The allele frequencies of the male were as follows:C=76.1%,T=23.9%and the genotype frequencies were as follows:C/C=59.2%,C/T=33.8%,T/T=7.0%;No significant difference was found in the frequencies of Cx37 gene C1019T genotype and alleles between men and women in Chinese Han population in Shannxi province.(P0.05).There were significant differences between Chinese Han population and Swedish population(P0.05),but no significant difference was detected between Chinese Han population and those in Japan and Taiwan(P0.05). Conclusion The frequencies of Cx37 gene C1019T genotype and allele in Shannxi Han population are not different from oriental population,but are different from Hesperian population.