Effects and adverse reactions of high-dose corticosteroids plus immunosuppressive therapy for treating hyperthyroidism eye diseases

Objective:To investigate the effects and adverse reactions of high-dose corticosteroids plus immunosuppressive therapy for hyperthyroidism eye disease and assess the clinical value of the treatment.Methods: A total of 64 patients were included in this study,who were hospitalized form Jan.2006 to Jan.2010 or as an outpatient,and were randomly divided into the high-dose methylprednisolone plus immunosuppressive therapy group(A),high-dose methylprednisolone therapy group(B),and conventional oral glucocorticoid hormone therapy group(C).Results: After six months of treatment,the efficacious rate in group A was significantly higher than that of the other two group(P0.05).The incidence of adverse reactions in group A was not different with that of group B(P0.05),but the incidence in group A and B was significantly lower than that of group C(P0.05).Conclusion: High-dose methylprednisolone plus low-dose immunosuppressive therapy for hyperthyroidism exophthalmos significantly improves clinical outcomes.The adverse events were not increased compared to the simple high-dose methylprednisolone therapy,and were decreased comparaed to conventional oral hormone therapy,which indicated that it is worthy of application widely.