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2014•Guiding Journal of Traditional Chinese Medicine and PharmacyRequires access

The Infection of Benzoin Extract on Lactate Dehydrogenase,Tumor Necrosis Factor and Interleukin-8 Activity in Endothelial Injury Cells

Xie Yu-pen

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Abstract

Objective: To research the regulation of Benzoin extract for inflammatory mediators LDH,TNF-α and IL-8 in endothelial cells and explore the mechanism of Benzoin treatment of atherosclerosis.Methods: Sublysis dose of C5b-9 was assembled on human umbilical vein endothelial cell surface in vitro by pure complement proteins assembly,and endothelial injury model was established.Groups were built;cells were cultured in different concentration drugs.Then the concentration of LDH,TNF-α and IL-8 in cell culture supernatant was measured by UV and Elisa kits.Results: LDH and IL-8 activity were reduced in extract high-dose group significantly vs model control group(P0.01),TNF-α levels was reduced in medium-dose groups vs model control group(P0.01).Conclusion: Benzoin may repair endothelial injury cells for therapy atherosclerosis by reducing the activity of inflammatory mediators LDH,TNF-α and IL-8.

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What this paper is about

Objective: To research the regulation of Benzoin extract for inflammatory mediators LDH,TNF-α and IL-8 in endothelial cells and explore the mechanism of Benzoin treatment of atherosclerosis.Methods: Sublysis dose of C5b-9 was assembled on human umbilical vein endothelial cell surface in vitro by pure complement proteins assembly,and endothelial injury model was established.Groups were built;cells were cultured in different concentration drugs.Then the concentration of LDH,TNF-α and IL-8 in cell culture supernatant was measured by UV and Elisa kits.Results: LDH and IL-8 activity were reduced in extract high-dose group significantly vs model control group(P0.01),TNF-α levels was reduced in medium-dose groups vs model control group(P0.01).Conclusion: Benzoin may repair endothelial injury cells for therapy atherosclerosis by reducing the activity of inflammatory mediators LDH,TNF-α and IL-8.

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Available abstract

Objective: To research the regulation of Benzoin extract for inflammatory mediators LDH,TNF-α and IL-8 in endothelial cells and explore the mechanism of Benzoin treatment of atherosclerosis.Methods: Sublysis dose of C5b-9 was assembled on human umbilical vein endothelial cell surface in vitro by pure complement proteins assembly,and endothelial injury model was established.Groups were built;cells were cultured in different concentration drugs.Then the concentration of LDH,TNF-α and IL-8 in cell culture supernatant was measured by UV and Elisa kits.Results: LDH and IL-8 activity were reduced in extract high-dose group significantly vs model control group(P0.01),TNF-α levels was reduced in medium-dose groups vs model control group(P0.01).Conclusion: Benzoin may repair endothelial injury cells for therapy atherosclerosis by reducing the activity of inflammatory mediators LDH,TNF-α and IL-8.

Key concepts: Lactate dehydrogenase, Umbilical vein, Benzoin, Tumor necrosis factor alpha, Human umbilical vein endothelial cell, Pharmacology, In vitro, Endothelial stem cell

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