Application of CT perfusion imaging in hepatic metastases

Objective To study hemodynamics characteristics of hepatic metastases by using CT perfusion imaging.Methods CT perfusion scans were performed in 25 cases with hepatic metastatic.The perfusion parameters of tumor tissue and peripheral liver parenchyma were measured,including the values of hepatic blood flow(HBF),hepatic blood volume(HBV),mean transit time(MTT),permeablility(PS),hepatic arterial fraction(HAP),and calculate hepatic arterial perfusion(HAP) and portal vein perfusion(PVP).Meanwhile,the time-density curve(TDC) and perfusion parameters characteristics of hypervasular as well as hypovascular metastases were analyzed.Results In the hypervasular metastases,the TDC was fast risen and slowly fallen,the tumor tissue was hypertransfusion obviously in HBF images.HBF,PS,HAF and HAP were superior to peripheral liver parenchyma while HBV,MTT and PVP were inferior to peripheral liver parenchyma.All parameters were statistically significant.In the hypovascular metastases,the TDC was slowly risen and slowly fallen,the tumor issue was hypotransfusion obviously in HBF images.HBF,HBV,MTT and PVP were inferior to peripheral liver parenchyma while PS and HAF were superior to peripheral liver parenchyma,in which HBF,HBV,MTT,HAF and PVP were ststistically significant.Conclusion CT perfusion imaging,which can reflect hemodynamic traits of hepatic metastases,has a great bearing on guiding the qualitation diagnosis and differential diagnosis.