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Protective effects of 3,6-dimethamidodibenzopyriodonium gluconate on focal cerebral ischemia-reperfusion injury in rats

Deng Xiu

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Abstract

Effects of 3,6 dimethamidodiben zopyriodonium gluconate(I 93) on focal cerebral ischemia reperfusion injury were studied in reversible cerebral middle artery occlusion model without craniectomy in rats. I 93 0.125,0.25 and 0.5 mg·kg -1 ip at 10 min before ischemia dose dependently inhibited the elevation of lactate dehydrogenase and creatine kinase activities in serum induced by cerebral ischemia for 3 h followed by reperfusion for 3 h, decreased the size of cerebral infarction and mortality of animal. I 93 0.5 mg·kg -1 also improved the brain ultrastructure damage. These results indicate that I 93 has protective effects against cerebral ischemia reperfusion injury.

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What this paper is about

Effects of 3,6 dimethamidodiben zopyriodonium gluconate(I 93) on focal cerebral ischemia reperfusion injury were studied in reversible cerebral middle artery occlusion model without craniectomy in rats. I 93 0.125,0.25 and 0.5 mg·kg -1 ip at 10 min before ischemia dose dependently inhibited the elevation of lactate dehydrogenase and creatine kinase activities in serum induced by cerebral ischemia for 3 h followed by reperfusion for 3 h, decreased the size of cerebral infarction and mortality of animal. I 93 0.5 mg·kg -1 also improved the brain ultrastructure damage. These results indicate that I 93 has protective effects against cerebral ischemia reperfusion injury.

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Available abstract

Effects of 3,6 dimethamidodiben zopyriodonium gluconate(I 93) on focal cerebral ischemia reperfusion injury were studied in reversible cerebral middle artery occlusion model without craniectomy in rats. I 93 0.125,0.25 and 0.5 mg·kg -1 ip at 10 min before ischemia dose dependently inhibited the elevation of lactate dehydrogenase and creatine kinase activities in serum induced by cerebral ischemia for 3 h followed by reperfusion for 3 h, decreased the size of cerebral infarction and mortality of animal. I 93 0.5 mg·kg -1 also improved the brain ultrastructure damage. These results indicate that I 93 has protective effects against cerebral ischemia reperfusion injury.

Key concepts: Ischemia, Medicine, Lactate dehydrogenase, Creatine kinase, Reperfusion injury, Anesthesia, Middle cerebral artery, Internal medicine

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Protective effects of 3,6-dimethamidodibenzopyriodonium gluconate on focal cerebral ischemia-reperfusion injury in rats — Research Paper | ScholarLens