Randomized controlled multicenter clinical trial on tazarotene cream versus adapaline gel in the treatment of acne vulgaris

Objective To evaluate the efficacy and safety of topical tazarotene 0.1% cream in the treatment of acne vulgaris. Methods A multicenter randomized single-blind controlled clinical trial was conducted. The patients with mild-to-moderate facial acne vulgaris were treated with either 0.1 % tazarotene cream or 0.1 % adapaline gel once daily for 8 weeks. Study visits took place at baseline and week 2,4 and 8. A total of 142 patients were enrolled in present clinical study.Among them, 71 patients were topically treated with 0.1 % tazarotene cream, in whicd 64 patients were evaluable for safety and efficacy. Seventy-one patients were topically treated with 0.1 % adapaline gel, in which 67 patients were evaluable for safety and efficacy. Results The results showed that total effective rate was 72.3% for tazarotene cream group, 62.7% for adapaline gel group(P0.05), respectively.Mild-to-moderate local skin irritation was found in 28.70% in tazarotene cream group and 23.50% in adapaline gel group(P0.05), respectively.Conclusion The present study suggests that 0.1% tazarotene cream was effective and safe for the treatment of acne vulgaris.