Protective Role of the Extract of Salvia Miltiorrhizabge. F. Alba. on Renal Function in the Rats of Diabetic Nephropathy

Objective To explore the impacts of the extract of salvia miltiorrhizabge. F. alba. on renal function in the rats of experimental diabetic nephropathy( DN) and determine its therapeutic effect. Methods Seventy-eight male Wistar rats fed with high-glucose and high-fat diet. The intravenous injection of streptozotocin( STZ),35 mg·kg-1in the tail was used to establish DN model. The rats were randomized into a blank group,a model group,a western medicine group,a big-dose Chinese medicine group,a middle-dose Chinese medicine group and a small-dose Chinese medicine group. Separately,in the 6th and 12th weeks,the levels of 24 h PRO、mAlb、FPG、Scr、BUN、TG、α1-MG and TRF were detected for statistical analysis. Results Compared with the model group,the therapeutic effect on blood glucose and renal function were significant in DF model rats of the Chinese medicine groups and the western medicine group. The levels of FPG,Scr,BUN,TG,24 h PRO,mAlb,α1-MG and TRF were better than those in the model group( P 0. 01). The efficacy was increasing significantly with the dose increase in the Chinese medicine treatment groups,in which,the effect was the best in the big-dose Chinese medicine group,apparently superior to the other groups( P 0. 01). Conclusion The extract of salvia miltiorrhizabge. f. alba has the significant protection on renal function of DN rats. It improves renal function and delays the progression of DN.