Effect of Complex Chinese Herbal Formula on Kidney Structure and Function in Rats with Early Experimental Diabetic Nephropathy

Objective To observe the effects of complex Chinese herbal formula with the actions of tonifying spleen and kidney and invigorating blood on kidney structure and function in rats with early diabetic nephropathy(DN),and to probe its mechanism.Methods Rat models of DN was induced by one-dose streptozocin(STZ)53 mg / kg i.p.Then the rats were randomized into Chinese medicine(complex formula)group,western medicine(Ruitai)group,model group and normal group.Biochemical parameters such as blood sugar,ratio of body weight and kidney weight,serum creatinine(SCr),blood urea nitrogen(BUN)and urinary micro-albumin(UAlb)and the changes of kidney structure in rats with DN were observed.Results Compared with the model group,the damage of kidney structure and the damage of renal function such as blood sugar,UAlb,SCr and BUN were obviously reduced in the other treatment group(P 0.01),and the effect of Chinese medicine was superior to the western medicine(P 0.01).Conclusion Complex Chinese herbal formula has preventive and therapeutic effect on early DN by lowering the blood sugar,UAlb,SCr,BUN,etc.