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2011•Chinese Journal of PharmaceuticalsRequires access

Optimization of the Extraction of Sanjiezhitong Cataplasm by Orthogonal Experiment and Multi-index Comprehensive Probabilistic Analysis Method

Limei Wang

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Abstract

To optimize the ethanol extraction conditions of Sanjiezhitong cataplasm including ethanol concentration,ethanol quantity and extraction time,orthogonal experiment and multi-index comprehensive probabilistic analysis method were used.The contents of parissaponinⅠ,parissaponin Ⅱ,ursolic acid and hypaconitine were determined by HPLC and chosen as evaluation indexes.The optimal extraction technology was 8 times 70% ethanol with two times extraction,each for 1.5 h.

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What this paper is about

To optimize the ethanol extraction conditions of Sanjiezhitong cataplasm including ethanol concentration,ethanol quantity and extraction time,orthogonal experiment and multi-index comprehensive probabilistic analysis method were used.The contents of parissaponinⅠ,parissaponin Ⅱ,ursolic acid and hypaconitine were determined by HPLC and chosen as evaluation indexes.The optimal extraction technology was 8 times 70% ethanol with two times extraction,each for 1.5 h.

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Available abstract

To optimize the ethanol extraction conditions of Sanjiezhitong cataplasm including ethanol concentration,ethanol quantity and extraction time,orthogonal experiment and multi-index comprehensive probabilistic analysis method were used.The contents of parissaponinⅠ,parissaponin Ⅱ,ursolic acid and hypaconitine were determined by HPLC and chosen as evaluation indexes.The optimal extraction technology was 8 times 70% ethanol with two times extraction,each for 1.5 h.

Key concepts: Chemistry, Extraction (chemistry), Chromatography, Ethanol, Ursolic acid, Biochemistry

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