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THE RELATIONSHIP BETWEEN APOLIPOPROTEIN H GENE POLYMORPHISM AND CORONARY HEART DISEASE

Y Wang

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Abstract

Objective To investigate the relationship between polymorphism of apolipoprotein H(ApoH) exon 3 and(exon 8) with coronary heart disease(CHD).MethodsPolymerase chain reaction and technique of restriction fragment length polymorphism were used to determine the genotypes of ApoH exon 3 and exon 8 in 110 patients with CHD and 100 healthy adults. Results The frequency of genotype GG of exon 3 in the CHD group was 81.8%;in GA+AA genotype,18.2%;in G allele,(88.0%);in A allele,12.0%.There was no significant difference compared with the controls(χ~2=2.147,1.454;P0.05).The frequency of GG genotype of exon 8 was 74.5%;GC genotype,25.5%;G allele,87.0%.GC genotype and C allele in CHD group were significantly higher than that in the control group(χ~2=7.742,3.907;P0.05).ConclusionThe polymorphism of the apolipoprotein H exon 3 has no relationship with CHD,but the GC genotype of ApoH exon 8 and C allele have close relation with CHD.

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Objective To investigate the relationship between polymorphism of apolipoprotein H(ApoH) exon 3 and(exon 8) with coronary heart disease(CHD).MethodsPolymerase chain reaction and technique of restriction fragment length polymorphism were used to determine the genotypes of ApoH exon 3 and exon 8 in 110 patients with CHD and 100 healthy adults. Results The frequency of genotype GG of exon 3 in the CHD group was 81.8%;in GA+AA genotype,18.2%;in G allele,(88.0%);in A allele,12.0%.There was no significant difference compared with the controls(χ~2=2.147,1.454;P0.05).The frequency of GG genotype of exon 8 was 74.5%;GC genotype,25.5%;G allele,87.0%.GC genotype and C allele in CHD group were significantly higher than that in the control group(χ~2=7.742,3.907;P0.05).ConclusionThe polymorphism of the apolipoprotein H exon 3 has no relationship with CHD,but the GC genotype of ApoH exon 8 and C allele have close relation with CHD.

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Available abstract

Objective To investigate the relationship between polymorphism of apolipoprotein H(ApoH) exon 3 and(exon 8) with coronary heart disease(CHD).MethodsPolymerase chain reaction and technique of restriction fragment length polymorphism were used to determine the genotypes of ApoH exon 3 and exon 8 in 110 patients with CHD and 100 healthy adults. Results The frequency of genotype GG of exon 3 in the CHD group was 81.8%;in GA+AA genotype,18.2%;in G allele,(88.0%);in A allele,12.0%.There was no significant difference compared with the controls(χ~2=2.147,1.454;P0.05).The frequency of GG genotype of exon 8 was 74.5%;GC genotype,25.5%;G allele,87.0%.GC genotype and C allele in CHD group were significantly higher than that in the control group(χ~2=7.742,3.907;P0.05).ConclusionThe polymorphism of the apolipoprotein H exon 3 has no relationship with CHD,but the GC genotype of ApoH exon 8 and C allele have close relation with CHD.

Key concepts: Genotype, Exon, Allele, Restriction fragment length polymorphism, Allele frequency, Genetics, Apolipoprotein B, Internal medicine

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