Clinical Observation on Therapeutic Effect of Bushen Huoxie Paidu Decoction in Retarding the Course of Chronic Renal Failure

Objective To observe the clinical curative effect of Bushen Huoxie Paidu decoction in delaying the renal fibrosis progression and retarding the course of chronic renal failure (CRF). Methods Seventy-six patients with CRF were randomly divided into the test group (38 cases) and the control group (38 cases). Both groups were treated with relatively unified fundamental treatment, experienced prescription of Bushen Huoxie Paidu decoction was given additionally to the test group. Treatment course of each group was 3 months. The curative effect was observed and the plasma levels of laminin (LN), fibronectin (FN), procollagen type Ⅲ (PC-Ⅲ) and collagen type Ⅳ (Ⅳ-C) in both groups were determined. Results The statistic analysis showed that the total effect of two groups (81.58% and 55.26%) had a significant difference (P0.01). The statistic analysis also showed that the test group could decrease LN, PC-Ⅲ, Ⅳ-C and increase FN, and was significantly different from that of control group respectively (P 0.01). Conclusion Bushen Huoxie Paidu decoction could markedly delay the renal fibrosis progression and retard the progression of CRF.