A multi-center clinical prospective study of N-acetylcysteine on severe hepatic disease

Objective To evaluate the effect and safety of N-acetylcysteine(NAC) on severe hepatic disease.Methods 230 patients with severe hepatic disease were divided into NAC group and control group.Patients in control group were treated with routine,and patients in NAC group were treated with the same therapeutic drugs used in control group plus a daily dose of 4 g NAC for 28 days.The symptom,harmful reaction,hepatic function and other biochemistry parameters were checked at day 0,21 and 28.Results In NAC group,the clinical symptom and the levels of ALT,AST,TBIL,PTA were improved obviously and the MELD and child' marks were decreased.There was significant difference between two groups.Conclusion The NAC can improve patients' clinical symptom and hepatic function and shows no serious adverse effect during the treatment period.