Clincal Observation on Combined Navelbine Intreatment of Advanced Non-small Cell Lung Cancer

Objective: To evaluate the results of combination chemotherapy with navelbine ( NVB ) plus ifosphamide (IFO) and cisplatin( DDP) . Methods:51 cases of advanced stages Ⅱb - Ⅳ NSCLC were histologically confirmed. Twenty - six patients were treated with NVB(25 -30 mg/m2 dl,8) plus IFO (3.0g/m2 dl) and DDP(50 -80 mg/ m2 dl)(N group). Another 25 cases received mitomycin C(MIT 60 mg/m2 dl) plus IFO(3.0g/m2 dl)plus DDP (50 - 80 mg/m ) ( M group) . Results: PR was seen in 12 cases of (N) group with an overall response of 46. 2% , while there were 8 PR cases in the (M) group with an overall response rate of 32. 0% . The overall rate of the(N) group was higher than that of (M) group No statistical difference was noted in overall response between the two groups. (P0.05). Karnofsky scores saw 69.2% (18 of 26) of case in the (N) group were increased, while 32. 0% (8 of 25 ) of cases in the ( M ) group (P 0. 05 ) . Neutropenia was the dose - limited toxicity and occurred in 73. 1% of patients in the (N) group and 72.0% in the (M) group. All of them are reversible after treatment. Local venous toxicity was observed in 34. 6% of the patients in the(N) group. Conclusion: A high response rate was obtained in advanced NSCLC treated by combination with NVB. Combination with NVB can be used as an alternative with tolerable toxicity.