Determination of Residual Organic Solvents in Cefetamet by Capillary Gas Chromatography with Headspace Sampling

Headspace gas chromatography method was used for the determination of four kinds of residual organic solvents in cefetamet. The samples were injected into DB-624capillary column by headspace sampler and analyzed with FID detector. The linear ranges of ethanol, acetone ,dichloromethane and tetrahydro furan were 0.2-7.0 mg·mL-1 (r=0.9995),0.2-7.0 mg·mL-1 (r=0.9994) ,0.03-1.0 mg·mL-1 (r=0.9993) and 0.02-0.9 mg·mL-1 (r=0.9994) respectively. The recoveries were 100.5 %,99.6 %,99.0 % and 98.4 % with RSD 1.2 %,2.3 %,1.8 % and 2.8 %(n=5) respectively. The method is simple, accurate and sensitive with good reproducibility. It can be used for the determination of the residual organic solvents in cefetamet.