Research on Early Stage Diabetic Nephropathy Based on Risk Factors

Objective:To explore the main risk factors related in early stage diabetic nephropathy( DN) and provide the basis for clinical treatment and prevention.Methods:182 patients multicentric with early DN were selected as observation group( group A),while 170 patients with the Type 2 diabetes mellitus and also without diabetic complications( T2DM,group B) were took as the control.The indexes in serum or urine were detected,which were glycosylated hemoglobin A1c( HbA1c) 、Triglyceride( TG) 、total cholesterol( TC) 、low density lipoprotein( LDL) 、high density lipoprotein( HDL) 、urinary albumin excretion rate( UAER),all patients ' clinical materials were collected,including age、duration of disease、waist-to-hip ratio( WHR) 、systolic and diastolic pressure,the levels of biological indexes were analyzed by the statistical method.Results:( 1) There was statistical significance in all the indexes above between group A and group B except age、TC and LDL( P 0.05,P 0.01);( 2) Logistic analysis showed that the main risk factors of early diabetic nephropathy were duration of diabetes,WHR,HbA1c,systolic pressure( P 0.01).( 3) Spearman analysis showed WHR positively correlated with TG and HbA1c( P 0.05);Positive correlation were also found between HbA1c and TG、duration of disease( P 0.05).Conclusion:Duration of diabetes,WHR,HbA1c,systolic pressure were the main risk factors in early DN.Control of hyperglycemia、blood pressure and weight loss can delay the development of diabetic nephropathy.