A analysis of correlation factors for peripheral arterial disease in diabetic nephropathy patients.

Objective To investigate the influential factors for peripheral arterial disease (PAD) in diabetic nephropathy patients.Methods A total of 337 type 2 diabetic patients with 235 patients having nephropathy (DN group) and 102 patients without nephropathy (DM group) were selected,and the ankle brachial index(ABI) and other indexes were measured.Results The incidence rate of PAD was higher (P0.05) in diabetic nephropathy group (63.0%) than in diabetes group(11.8%).The difference in systolic blood pressure (SBP),diastolic blood pressure (DBP),low-density lipoprotein (LDL),fasting serum glucose,glomerular filtration rate(GFR),fibrinogen (FBG),urinary albumin/creatinine (UA1b/ Cr),24-hour urinary protein excretion and age showed statistical significance among groups of DN PAD+,DN PAD-,DM PAD+,DM PAD-.The possible influential factors for diabetic nephropathy group were SBP,UAlb/Cr,GFR,24-hour urinary protein excretion.The possible influential factors for diabetes mellitus group were SBP,DBP,24-hour urinary protein excretion.Conclusions The SBP, fibrinogen and urinary protein may be the predicting factors for lower extremity arterial disease.