Strategies and Choices of Construction of Targeted Ultrasound Microbubbles

By virtue of inherent biological characteristics of the surface of ultrasound microbubbles,or connecting specific ligand to the surface of ultrasound microbubbles through special treatment,targeted ultrasound microbubbles can be constructed.Via intravenous injection,the targeted ultrasound microbubbles can gather at the target tissue or target organ and remain there for a long time,so molecular imaging can be produced by contrast-enhanced ultrasound.Experimental studies have shown that targeted contrast-enhanced ultrasound can evaluate the lesions of the target tissues and organs,such as vascular endothelial injury/inflammation,thrombosis and tumour angiogenesis in quantitative and non-invasive manner.Studies in the construction of targeted ultrasound microbubbles,which is the key part of targeted contrast-enhanced ultrasound technology,have evolved rapidly in recent years.