Expression and clinical significance of PTEN in non-small cell lung cancer

Objective:To investigate the non-expression of PTEN in non-small cell lung cancer and the relationship between the non expression of PTEN and clinincal and pathologic parameters.Methods:To use immunohistochemistry(S-P) method to evaluate PTEN protein expression situation in non-small cell lung cancer and adjacent tissues.Results:In nonsmall cell lung cancer,the positive expression rate of PTEN protein was 30.00%(12/40).In adjacent lung tissue the positive expression rate of PTEN protein was 100.00%(40/40).The positive expression of Lung tissue was significantly lower than the adjacent lung tissue(χ2=37.48,P0.05),in well-differentiated cancer the PTEN positive rate was 83.33%(15/18),in poorly differentiated carcinoma and the positive rate was 27.27%(6/22),the difference was statistically significant(χ2=12.76,P= 0.00).Clinical stage,in I + II stage PTEN positive rate was 70.83%(17/24),in the III + IV,the positive rate was 31.25%(5/16),the difference was statistically significant(χ2=6.77,P=0.01);in cases without lymph node metastasis,PTEN positive rate was 80.00%(16/20),in cases with lymph node metastasis positive rate was 35.00%(7/20),the difference was statistically significant(χ2=9.05,P=0.00).There was no relationship between PTEN expression and the histology,sex,age,tumor size(P0.05);otherwise,there was closely relationship between PTEN expression and the degree of differentiation of tumor and clinical staging,lymph node metastasis(P0.05).Conclusion:It is possible correlation between the loss or non-expression of PTEN protein and the occurrence and development of non-small cell lung cancer.