Observation of the curative effects of intravenous thrombolysis with recombinant tissue-type plasminogen activator on treating acute cerebral infarction

Objective To observe the efficacy and safety of intravenous thrombolysis with recombinant tissue-type plasminogen activator(rt-PA) on treating acute cerebral infarction(ACI).Methods Thirty ACI patients onset within 3 h were divided into rt-PA group and control group.Both of them had routine therapy of ACI.Then,the patients in the rt-PA group received intravenous thrombolysis with rt-PA,and the control group received the therapy of Ozagrel Sodium.Before and after treatment,Natinal Institute of Health Stroke Scale(NIHSS) and Barthel Index(BI) were applied to assess the efficacy and safety.The efficacy and safety were compared between the two groups.Results The scores of NIHSS after treatment were significantly better than before treatment in the both groups,and the improvement in the rt-PA group was much greater than control group(P0.05-0.01).At 21 d after treatment,the rates of effectual(80%) and BI≥95(40%) in the rt-PA group were significantly higher than those in the control group(20%,0)(allP0.01).The mortality and incidence of secondary intracerebral hemorrhage or vascular reocclusion in the two groups had no ststistical difference.Conclusion ACI patients onset within 3 h treated by intravenous thrombolysis with rt-PA will have better efficacy than Ozagrel Sodium and more safe.