Influence of unilateral amyloid-β_(25-35) injections into the amygdala on the spatial learning and memory ability and the expression of synaptophysin in hippocampus of rats

Objective To explore the relationship between the expression of synaptophysin(SYN) in hippocampus and cognitive function in dementia model rats.Methods The dementia rat model was made by unilateral Aβ_(25-35)injecting into the amygdala.The spatial learning and memory ability were observed by means of Morris water maze experiment.The protein expression of SYN was estimated with immunohistochemistry.Results The results of Morris water maze indicated that both spatial learning and memory ability in model group rats were impaired seriously compared with the control group rats.The positive cell numbers and optical density of SYN in hippocampus of the model group rats decreased remarkably.Conclusion The synapses reduction in hippocampus is probably related to the impairment of spatial learning and memory in dementia model rats.