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Pharmacokinetics of nobiletin in rats and Beagle dogs

Jiake He

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Abstract

AIM: To investigate the pharmacokinetics of nobiletin in rats and Beagle dogs.METHODS: The concentration of nobiletin in plasma was measured by HPLC after intragastric administration and intravenous injection.RESULTS: In rats,the tmax values of nobiletin by intragastric administration at doses of 8,16 and 32 mg/kg were 20,30 and 30 min,respectively,and the Cmax values were(300±171),(468±122) and(982±449) ng/mL respectively and the bioavailability was(14.6±2.7)%.In Beagle dogs,the tmax value of nobiletin after oral administration at a single dose of 4 mg/kg was(95±12) min,the Cmax value was(435.6±88.1) ng/mL and the bioavailability was(27.4±8.4)%.CONCLUSION: After oral administration,nobiletin was rapidly absorbed in rats and Beagle dogs,but had low bioavailability.The values of tmax,t1/2α and t1/2β were different between the two species of animals obviously.

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AIM: To investigate the pharmacokinetics of nobiletin in rats and Beagle dogs.METHODS: The concentration of nobiletin in plasma was measured by HPLC after intragastric administration and intravenous injection.RESULTS: In rats,the tmax values of nobiletin by intragastric administration at doses of 8,16 and 32 mg/kg were 20,30 and 30 min,respectively,and the Cmax values were(300±171),(468±122) and(982±449) ng/mL respectively and the bioavailability was(14.6±2.7)%.In Beagle dogs,the tmax value of nobiletin after oral administration at a single dose of 4 mg/kg was(95±12) min,the Cmax value was(435.6±88.1) ng/mL and the bioavailability was(27.4±8.4)%.CONCLUSION: After oral administration,nobiletin was rapidly absorbed in rats and Beagle dogs,but had low bioavailability.The values of tmax,t1/2α and t1/2β were different between the two species of animals obviously.

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Available abstract

AIM: To investigate the pharmacokinetics of nobiletin in rats and Beagle dogs.METHODS: The concentration of nobiletin in plasma was measured by HPLC after intragastric administration and intravenous injection.RESULTS: In rats,the tmax values of nobiletin by intragastric administration at doses of 8,16 and 32 mg/kg were 20,30 and 30 min,respectively,and the Cmax values were(300±171),(468±122) and(982±449) ng/mL respectively and the bioavailability was(14.6±2.7)%.In Beagle dogs,the tmax value of nobiletin after oral administration at a single dose of 4 mg/kg was(95±12) min,the Cmax value was(435.6±88.1) ng/mL and the bioavailability was(27.4±8.4)%.CONCLUSION: After oral administration,nobiletin was rapidly absorbed in rats and Beagle dogs,but had low bioavailability.The values of tmax,t1/2α and t1/2β were different between the two species of animals obviously.

Key concepts: Beagle, Nobiletin, Bioavailability, Cmax, Pharmacokinetics, Oral administration, Pharmacology, Chemistry

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