2010•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access

Comparison of the pharmacokinetics of BAPTA-AM liposome injection in rats and Beagle dogs

Wei Wei

Abstract

AIM:To compare the pharmacokinetics of BAPTA-AM liposome injection in rats and Beagle dogs.METHODS:The concentration of BAPTA-AM in plasma was quantified by LC-MS/MS after intravenous injection.The pharmacokinetic parameters were calculated by the non-compartment model.RESULTS:The elimination half-life in rats after intravenous injection 1.5,3.0 and 6.0 mg/kg BAPTA-AM liposome were (255±140),(290±260)and (376±257)min respectively,and the AUC0-∞ were(831±251),(1467±528)and(3650±1664) μg·L-1·min,respectively.The elimination half-life in dogs after intravenous injection 0.5,1.0 and 2.0 mg/kg BAPTA-AM liposome were (362±305),(347±278)and (432±292)min respectively,and the AUC0-∞ were (400±118),(569±139)and (1185±640) μg·L-1·min,respectively.CONCLUSION:After intravenous injection,BAPTA-AM liposome is metabolized rapidly and distributed abroad in rat and Beagle dog.There is no difference in the pharmacokinetic between rats and dogs.

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Key concepts: Beagle, Pharmacokinetics, Liposome, Pharmacology, Chemistry, Medicine, Internal medicine, Biochemistry