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2006•Unpublished venueRequires access

Expressions of vascular endothelial growth factor in non-small cell lung cancer

Ke Liang

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Abstract

Objective To investigate the expressions of vascular endothelial growth factor(VEGF) in Non-Small Cell Lung Cancer(NSCLC)and its relationship to histopathological features. Methods The expressions of VEGF was observed by immunohistochemical methods in 58 cases of non-small cell lung cancer and 25 cases of non-lung cancer tissue. Results The positive rates of VEGF in NSCLC were 43.1 % which was significantly higher than those in non-lung cancer tissue(14.3 %, P 0.01). The expressions of VEGF have no significant relationship with pathological grade and histological types. The expressions of VEGF was related to lymph nodes metastasis and survival time (P 0.05 or P 0.01). Conclusion VEGF over expression may be a biological marker in non-small cell lung cancer, and it may serve as a significant marker for predicting the metastasis and the prognosis of non-small cell cancer patients.

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Objective To investigate the expressions of vascular endothelial growth factor(VEGF) in Non-Small Cell Lung Cancer(NSCLC)and its relationship to histopathological features. Methods The expressions of VEGF was observed by immunohistochemical methods in 58 cases of non-small cell lung cancer and 25 cases of non-lung cancer tissue. Results The positive rates of VEGF in NSCLC were 43.1 % which was significantly higher than those in non-lung cancer tissue(14.3 %, P 0.01). The expressions of VEGF have no significant relationship with pathological grade and histological types. The expressions of VEGF was related to lymph nodes metastasis and survival time (P 0.05 or P 0.01). Conclusion VEGF over expression may be a biological marker in non-small cell lung cancer, and it may serve as a significant marker for predicting the metastasis and the prognosis of non-small cell cancer patients.

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Available abstract

Objective To investigate the expressions of vascular endothelial growth factor(VEGF) in Non-Small Cell Lung Cancer(NSCLC)and its relationship to histopathological features. Methods The expressions of VEGF was observed by immunohistochemical methods in 58 cases of non-small cell lung cancer and 25 cases of non-lung cancer tissue. Results The positive rates of VEGF in NSCLC were 43.1 % which was significantly higher than those in non-lung cancer tissue(14.3 %, P 0.01). The expressions of VEGF have no significant relationship with pathological grade and histological types. The expressions of VEGF was related to lymph nodes metastasis and survival time (P 0.05 or P 0.01). Conclusion VEGF over expression may be a biological marker in non-small cell lung cancer, and it may serve as a significant marker for predicting the metastasis and the prognosis of non-small cell cancer patients.

Key concepts: Lung cancer, Vascular endothelial growth factor, Immunohistochemistry, Pathological, Medicine, Metastasis, Pathology, Lung

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