Protective effect of Ligustrazine on pancreata and renal injury of rats with acute necrotizing pancreatitis

Objective: To explore the therapeutic effectiveness of Ligustrazine on pancreata and renal injury following acute necrotizine pancreatitis(ANP).Methods: 192 rats were randomly divided into control group(C group),ANP group without treatment(P group),ANP group treated with Ligustrazine(T group).The renal blood flow was measared at 0.5,2,6 and 12h after the models had been made.The pathological changes of pancreas,kidney and the renal function and TXA_2/PGI_2 were observed.Results: Comparing with C group,the renal blood flow in P group was decreased significantly(P0.01).Serious renal and pancreatic damages were found in P group,and the BUN, Cr levels were elevated significantly(P0.05),and the TXA_2/PGI_2 was increased at 2,6,12h(P0.01).Contrasted with P group,the blood flow of kidney in T group was elevated significantly at 6,12h(P0.01),the renal and pancreatic damages were attenuated,the BUN,Cr levels were decreased significantly(P0.05), and the TXA_2/PGI_2 were decreased at 6,12 h((P0.05).) Conclusion:Ligustrazine can alleviate the damage of pancreas and kidney of rats with ANP.