X chromosome abnormalities and genetic analysis of clinical

Objective: To investigate the clinical features of X chromosome abnormalities and to analyze its possible causes.Methods: 5268 cases of reproductive abnormalities in patients with peripheral blood lymphocytes by culture,chromosome banding karyotype analysis.X chromosome abnormalities were detected in 79 cases,accounting for 1.49% of patients were seized.X chromosome abnormalities in which the number of 64 cases,accounting for 81.0% of abnormal karyotypes.Abnormal X chromosome mosaicism in 7 cases,accounting for 8.9% of abnormal karyotypes.X chromosome structural abnormalities in 5 cases,accounting for 6.3% of abnormal karyotype.X chromosome structural abnormalities,and 3 cases of chimeras,accounting for 3.8% of abnormal karyotype.Conclusion: X chromosome abnormalities can lead to abnormal sexual development or repro ductive abnormalities and other genetic effects,in genetic counseling should be taken seriously enough for clinical diagnosis and treatment are important.