Clinical observation of filtering bleb infections and filtration bleb-related endophthalmitis after glaucoma surgery

OBJECTIVE To discuss the risk factors for filtering bleb infections and filtration bleb-related endophthalmitis after glaucoma surgery and the clinical manifestation as well as the prognosis outcomes.METHODS The medical cases with filtering bleb infections who underwent glaucoma surgery in recent 5 years were retrospectively investigated,those participants were divided into two groups according to the intraoperative placing MMC,the possibility of placing MMC in increasing the risk of filtering bleb infections was discussed.The filtering bleb infection cases were divided into the simple infection group and the endophthalmitis group,the clinical manifestations,etiology,treatment,and the clinical prognosis were discussed.RESULTS The incidence of postoperative bleb infections in the non-antimetabolites group was 0.44%,the antimetabolites group 1.36%,the difference was statistically significant(P0.05);the intraocular pressure of the simple herpes bleb infection group before and after the treatment were(16.25±3.30) mmHg and(14.88±3.42) mmHg,respectively;while(18.36±14.12)mmHg and(15.00±3.12)mmHg in the endophthalmitis group,the difference was not statistically significant;as for the etiology examination,there were 8 cases with gram-negative bacteria infections and 7 cases with gram-positive bacteria infections in the endophthalmitis group,while 7 cases and 3 cases respectively in simple herpe bleb infections group,the difference was not statistically significant.CONCLUSION A single application of intraoperative antimetabolite drugs can effectively improve the filtering bleb function change rate,but it is closely related to the filtering bleb infections so that it should be used painstakingly.