Value and impact factors of transient elastography in diagnosis of hepatitis B cirrhosis

Objective To investigate the value and the effects of transient elastography instrument fibroscan(FS) for diagnosis of liver cirrhosis in patients with chronic hepatitis B.Methods Two hundred and thirty-nine patients with chronic hepatitis B were enrolled in this study.All of the patients underwent liver stiffness measurement(LSM) by FS before liver biopsy.Simultaneously,the relative detections were performed in serum biochemical parameters such as alanine aminotransferase(ALT),aspartate transaminase(AST),total bilirubin(TBIL),direct bilirubin(DBIL),total protein(TP),albumen(A),globulin(G) and A/G.With the liver biopsy as the gold standard,the liver fibrosis stage and inflammation grade were executed.The receiver operating characteristic(ROC) curve was adopted to analyze the accuracy of FS for diagnosing liver fibrosis,and the relationship of LMS between liver cirrhosis and non-cirrhosis was compared.Results The LSM of cirrhotic patients was significantly higher than that of non-cirrhotic patients,26.3(63.4) kPa vs 7.0(33.5) kPa(P0.01).ROC area under the curve of LSM for diagnosis of liver cirrhosis was 0.954,the sensitivity and specificity were 0.98,0.83,respectively.Multivariate regression analysis showed that LSM in patients with liver cirrhosis had linear regression with patients' age,the regression coefficients 0.335,P0.05.Conclusion FS has very good value for diagnosing liver cirrhosis in patients with chronic hepatitis B,and the influencing factors are less,and FS is helpful to the differential diagnosis and prognostic assessment of patients with cirrhosis.