The association study of resistin-420C/G polymorphism with type 2 diabetes mellitus macroangiopathy in Han population of Northeast China

Objective To investigate the relationship between matrix metalloproteinase-2(MMP-2),tissue inhibitor of metalloproteinase-1(TIMP-1) and hs-CRP in type 2 diabetes mellitus(T2DM) with carotid atherosclerosis(CAS).Methods A total 0f 62 patients with T2DM were recruited to our study.The intima-media thickness(IMT) and plaques of carotid artery were measured.These patients were divided into 3 groups according to their IMT values:diabetes mellitus(DM) group(n=21),carotid artery intima thicken group(n=21) and carotid artery intima plaque group(n=20).At the sane time,20 healthy individuals were selected as control.Serum level of MMP-2,TIMP-1 and hs-CRP were determined and analyzed.Results Compared with the normal control group,the serum levels of MMP-2,hs-CRP were elevated,while TIMP-1 was reduced,the difference was statistically significant(P0.05 or P0.01);compared with DM group,the serum levels of MMP-2,hs-CRP in intima thicken group were elevated,while TIMP-1 was reduced,the difference was statistically significant(P0.05);the serum levels of MMP-2,hs-CRP was higher in plaque group than in DM group and intima thicken group,the serum levels of TIMP-1 was lower in plaque group than in DM group and intima thicken group,the difference was statistically significant(P0.05 or P0.01).Conclusion The severity of carotid atherosclerosis inT2DM is closely associated with the serum MMP-2,hs-CRP level and TIMP-1.