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Association of serum MMP-9 and carotid intima-media thickness in elderly patients with type 2 diabetes

Shi Yi-shan

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Abstract

Objective: To investigated the association of serum matrix metalloproteinase-9(MMP-9) and carotid intima-media thickness(IMT) in elderly patients with type 2 diabetes mellitus(T2DM).Methods: A total of 66 elderly patients with T2DM were recruited.These patients were further divided into 3 groups according to IMT.18 cases of DM group,23 cases of incrassation group and 25 cases of plaque group.20 elderly healthy controls were selected.Serum level of MMP-9 were determined.Results: The serum MMP-9 in diabetic patients of DM group(576.43±257.93)μg·L-1 were higher than that in healthy controls(387.70±243.71)μg·L-1(P0.05).The diabetic patients of incrassation group(694.58±315.26)μg·L-1 and plaque group(882.74±286.44)μg·L-1 were higher than that in DM group and healthy controls(P0.05).Conclusion: The severity of carotid atherosclerosis(AS) in elderly patients with T2DM is closely associated with the increase of serum MMP-9.

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Objective: To investigated the association of serum matrix metalloproteinase-9(MMP-9) and carotid intima-media thickness(IMT) in elderly patients with type 2 diabetes mellitus(T2DM).Methods: A total of 66 elderly patients with T2DM were recruited.These patients were further divided into 3 groups according to IMT.18 cases of DM group,23 cases of incrassation group and 25 cases of plaque group.20 elderly healthy controls were selected.Serum level of MMP-9 were determined.Results: The serum MMP-9 in diabetic patients of DM group(576.43±257.93)μg·L-1 were higher than that in healthy controls(387.70±243.71)μg·L-1(P0.05).The diabetic patients of incrassation group(694.58±315.26)μg·L-1 and plaque group(882.74±286.44)μg·L-1 were higher than that in DM group and healthy controls(P0.05).Conclusion: The severity of carotid atherosclerosis(AS) in elderly patients with T2DM is closely associated with the increase of serum MMP-9.

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Available abstract

Objective: To investigated the association of serum matrix metalloproteinase-9(MMP-9) and carotid intima-media thickness(IMT) in elderly patients with type 2 diabetes mellitus(T2DM).Methods: A total of 66 elderly patients with T2DM were recruited.These patients were further divided into 3 groups according to IMT.18 cases of DM group,23 cases of incrassation group and 25 cases of plaque group.20 elderly healthy controls were selected.Serum level of MMP-9 were determined.Results: The serum MMP-9 in diabetic patients of DM group(576.43±257.93)μg·L-1 were higher than that in healthy controls(387.70±243.71)μg·L-1(P0.05).The diabetic patients of incrassation group(694.58±315.26)μg·L-1 and plaque group(882.74±286.44)μg·L-1 were higher than that in DM group and healthy controls(P0.05).Conclusion: The severity of carotid atherosclerosis(AS) in elderly patients with T2DM is closely associated with the increase of serum MMP-9.

Key concepts: Medicine, Internal medicine, Intima-media thickness, Type 2 Diabetes Mellitus, Diabetes mellitus, Gastroenterology, Matrix metalloproteinase 9, Matrix metalloproteinase

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