Effects of Lumbricus Capsule on IL-6,IL-8,IL-10 and TNF-α in patients with acute cerebral infarction

Objective:To observe the effects of Lumbricus Capsule on expression of serum IL-6,IL-8,IL-10 and TNF-α levels in acute cerebral infarction patients.Methods:80 cases of acute cerebral infarction patients were randomly divided into the treatment group(Lumbricus Capsule+routine therapy) and the control group(conventional therapy),before and after the treatment 10 d serum IL-6,IL-8,IL-10 and TNF-α levels were detected,the data was compared before and after the treatment.Results:Two groups in treatment of acute cerebral infarction patients serum IL-6 [the treatment group and the control group respectively was(75.62±3.02) pg/ml,(73.95±4.31) pg/ml],IL-8 [the treatment group and the control group respectively was(1.58±0.21) ng/ml,(1.61±0.33) ng/ml],IL-10 [the treatment group and the control group respectively was(53.69±5.63) pg/ml,(57.34±4.34) pg/ml]and TNF-α [the treatment group and the control group respectively was(3.65±0.62) pg/ml,(3.83±0.74) pg/ml] before the treatment were higher than normal group,serum IL-10 [the treatment group,the normal group and the control group respectively was(5.78±4.85) pg/ml,(6.76±5.57) pg/ml,(27.64±5.78) pg/ml] was lower than the normal group,differences was statistically significant(P0.05),but comparative differences between the two groups was statistically significant(P0.05).After the treatment of two groups serum IL-6[the treatment group and the control group respectively was(25.78±5.35) pg/ml,(38.49±5.25) pg/ml],IL-8[the treatment group and the control group respectively was(0.78±0.25) ng/ml,(1.31±0.24) ng/ml],IL-10 [the treatment group and the control group respectively was(5.78±4.85) pg/ml,(16.76±5.57) pg/ml] and TNF-α [the treatment group and the control group respectively was(1.45±0.35) pg/ml,(2.65±0.56) pg/ml] of patients before were higher than normal group,The treatment group particularly was evident(P0.05).Conclusion:Monitoring serum IL-6,IL-8,IL-10 and TNF-α level is helpful to identify cerebral infarction outcome.Monitoring serum IL-6,IL-8,IL-10 and TNF-α level helps determine the prognosis of cerebral infarction;application of Lumbricus Capsule can dramatically reduce serum IL-6,IL-8,IL-10 and TNF-α level of patients,hence relieve brain damage,which is beneficial to the outcome in patients with cerebral infarction.