2011•Zhongguo redai yixueRequires access
The effect of Shenditangmaining on the lipid metabolism and cytokine in diabetic rats
Xue Zhang
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Abstract
Aim To investigate the impact of Shenditangmaining on the lipid metabolism and cytokine in diabetic rats.Methods Diabetic model was induced in male SD rats by intraperitoneal injection of streptozotocin(60 mg/kg).The rats were divided into three groups :diabetic group,aspirin diabetic group,Shenditangmaining diabetic group.The age and weight matched normal male SD rats served as control group.The rats of aspirin diabetic group were fed with aspirin 30mg/kg.d.The rats of Shenditangmaining diabetic group were fed with 5g/kg.d Shenditangmaining solution.The rats of diabetic group and control group were fed with equal cubage of distilled water.Before treatment,6-week treatment and 12-week after treatment,the levels of TG,TC,LDL,HDL and VLDL were evaluated.Before treatment and after12-week treatment,TNFα and IL-6 were analyzed with Enzyme-linked immunosorbent(ELISA).Results Compared with the control group,the levels of TG,TC,LDL and VLDL in the diabetic group were increased significantly(P0.05).The levels of IL-6 and TNFα was higher than control group(P0.01).Compared with the diabetic group the levels of TG,TC,LDL and VLDL in the Shenditangmaining diabetic group decreased significantly(P0.05) 6 weeks and 12 weeks after treatment.Furthermore the reduction of the Shenditangmaining diabetic group was higher than that of the aspirin diabetic group(P0.05).The levels of TNFα and IL-6 in the diabetic group was higher than the control group(P0.01).The level of TNFα and IL-6 in aspirin diabetic group and Shenditangmaining diabetic group decreased 12 weeks after treatment compared to diabetic group(P0.01).There was significantly differences between the aspirin diabetic group and the Shenditangmaining diabetic group(P0.05).Cconclusion Shenditangmaining may ameliorate blood lipid and antagonize inflammatory in experimental diabetic rats.