C-reactive Protein is elevated in Coronary Artery Disease Patients with Type 2 Diabetes Mellitus

Objective To investigate C-reactive protein level in coronary heart disease patients with type 2 diabetes mellitus compared with those without diabetes. Methods 53 coronary heart disease patients with type 2 diabetes mellitus and 38 without diabetes were measured serum CRP by enzyme-linked immunoabsorbent assay. All the patients were documented by angiogram. Results C-reactive protein was significantly increased in coronary artery disease patients with diabetes compared with those without diabetes (2.95±2.42mg/L vs 1.23±0.95mg/L; P0.01). Moreover, CRP level in diabetic patients with previous myocardial infarction increased significantly compared with those previous myocardial infarction patients without diabetes (3.35±2.24mg/L vs 1.21±1.15 mg/L; P0.01). Univariate analysis implied that CRP levels were positively associated with serum total cholesterol, LDL cholesterol, triglyceride, and negatively associated with high density lipoprotein cholesterol. Conclusion CRP level was significantly elevated in coronary artery disease patients with type 2 diabetes, which implied that inflammation might play an important role in the coronary artery disease with diabetes, and diabetes promotes atherosclerosis.