Clinical value of serum cystatin C in determination of renal function impairment in neonatal asphyxia

Objectives To evaluate the clinical value of serum cystatin C(Cys C) in determination of renal function impairment in neonates with asphyxia.Methods The serum concentration of Cys C,SCr and BUN was measured in 146 neonatal asphyxia(70 mild and 76 severe asphyxia) 24hr-36hr after birth.Control group included 100 neonates without perinatal asphyxia and other factors that can result in renal function impairment.Relationship between the changes of level of serum Cys C and SCr,BUN were analyzed.Results(1) There were no significant differences in concentration of serum Cys C,SCr and BUN between mild neonatal asphyxia and the controls,while the levels of Cys C,SCr and BUN in severe asphyxia newborns were markedly higher than that of the controls.(2) The rate of higher serum Cys C in severe asphyxia newborns was 44.7%,which is higher than that of BUN and SCr(both P 0.05).Conclusions Serum Cys C is superior to serum SCr and serum BUN in evaluation of kidney function.