Construction of universal quantitative models for determination of cefradine capsules

Objective:To develop a near infrared (NIR)method for rapid determination of cefradine capsules. Methods:The diffuse reflectance near-infrared spectra of cefradine capsules fiom different pharmaceutical facto- ries in China were determined by a fibre optic probe.The first derivative followed by vector normalization method was used for spectra pretreating and 9751-7498.4 cm~(-1) was selected as the frequency range.The calibration model was developed using the partial least squares (PLS)algorithm.Results:100 batches of cefradine capsules samples were used as calibration set,and 46 batches as validation set.The correlation coefficient of the calibration set was 0.9693,the RMSECV (root mean square error of cross validation) was 1.70%,the average relative deviation for the validation set was 2.4% and the RMSEP(root mean square error of prediction)was 2.24%.Conclusion:The NIR- DRS result is exact.The method is simple,rapid,and can be applied to fast drug analysis.