Efficacy and safety of losartan in treatment of mild and moderated hypertension

AIM To observe the efficacy and safety of losartan during 12 week treatment of mild and moderated hypertension, using randomored double blind control observation method. METHODS One hundred and fifty six patients with essential hypertension were recruited according to the established criteria, and randomized into treatment and control groups; seventy eight patients were divided into three groups according to those ages and treated with losartan with50~100 mg·d -1 for 12 weeks. The others received enalapril 10 mg or 20 mg daily for 12 weeks. The efficacy and safety were evaluated with clinical, biochemical and blood pressure parameters. RESULTS Ambulatory blood pressure monitoring showed that compared with the pre treatment states the SBP and DBP of the treatment were significantly reduced by (3.09±0.6) kPa, (2.2±0.5) kPa and similar to control group's which reduced by (3.2±0.4) kPa, (2.6±0.5) kPa respectively; however, in the treatment group, significant difference were not found among the three age's groups, no changes in heart rate, blood parameters and intolerance adverse effects were found during the study. CONCLUSION Losartan is an effective and safe agent for the treatment of mild to moderate hypertension of all ages.