Expression and clinical significance of inducible nitric oxide synthases in laryngeal carcinoma

Objective:To observe the expression of inducible nitric oxide synthases(iNOS) in laryngocarcinoma tissues and its role in the invasion and metastasis of laryngeal carcinoma.Methods:The expression of iNOS in 66 cases of laryngealcarcinoma tissues and the normal mucous membrane were detecdted by immunohistochemistry S-P method.The correlation between the expression of iNOS and the clinical stage,clinical classification,pathological grade and lymph node metastasis of laryngeal carcinoma was analyzed.Results:The positive rate of iNOS in laryngealcarcinoma tissues and the normal mucous membrance was 81.82% and 6.06%,respectively(P0.05);the expression of iNOS was significantly correlated with the clinical stage and classification of patients with laryngeal carcinoma(P0.05),but had no relation with the patients′age,pathological grade or lymph node metastasis(P0.05).Conclusions:iNOS may act as an important tumor marker in lymph node metastasis of laryngeal carcinoma.It plays an important role in the invasion,metastasis and prognosis of laryngeal carcinoma.