Effect of the levonorgestrel-releasing intrauterine system for the morphometry of endometrial hyperplasia

Objective To study the effect of the levonorgestrel-releasing intrauterine system(LNG-IUS) for the morphometry of endometrial hyperplasia.Methods The morphotric parameters including endometrial hyperplasia treated with LNG-IUS before and after 3 months were measured in 20 cases by using computerized imaged analysis system and compared with the morphotric parameters of endometrial hyperplasia treated with norethisterone in 20 cases.Results After insertion of LNG-IUS,the endometrial number of glands,the number of glandular mitoses,the number of stroma mitoses,the diameter of the glandular lumen and the height of glandular epithelium were decreased(P0.05).Comparison of the effect of LNG-IUS and norethisterone on the endometrial activity,among the indices measured,significant differences were found in the number of glands and glandular diameter(P0.05).Conclusion By using objective morphometric treatment monitoring,it can be revealed that the LNG-IUS has a very strong restraining for endometria hyperplasia and this device shows more superior regression of hyperplasia.