Clinical and ultrastructural studies of endometrial levonorgestrel-releasing intrauterine system in the treatment of endometrial hyperplasia

Objective This study aimed to investigate the levonorgestrel-releasing intrauterine system(LNG-IUS) Endometrial hyperplasia of the endometrium ultrastructural changes in treatment. Methods The patients in our hospital, OK LNG-IUS treatment of 45 cases of endometrial hyperplasia. 3,6,12 months of treatment, respectively ultrasound testing, diagnostic curettage, menstrual flow was observed in patients with change, a change in endometrial thickness and pathology, and pathology specimens electron microscopy to understand the endometrium Supermicro structural changes. The results: LNG-IUS treatment can significantly reduce(P 0.05) menstrual flow, endometrial thickness lower(P 0.05), the performance of electron microscopy after treatment: ciliated epithelial cells lining the gap widened, intracellular visible nuclear debris, endoplasmic reticulum, mitochondria swelling, cristae disappear. Compared with the number of secretory cells before treatment significantly reduced micro velvet underdeveloped, fragmented nuclei change. Mesenchymal cells become large, rich organelles, nuclear, rich euchromatin, was decidua-like cells. Conclusion LNG-IUS treatment of endometrial hyperplasia is safe and effective.