Effects of Serum Insulin-like Growth Factor-1 and Nitric Oxide Levels in Patient with Essential Hypertension

Objective To investigate the changes of serum Insulin-like growth factor-1(IGF-1) and nitric oxide(NO) levels in patient with essential hypertension(EH).Methods From 2004 35 patients with essential hypertensions and 25 normotensive in Affiliated hospital of Dalian University,Serum IGF-1 levels were measured by radioimmunoassay method respectively and NO levels were measured by nitrate reductase method respectively.Results Base line IGF-1 serum level were higher in EH than in normal controls(14.11±2.46nmol/l Vs 10.77±3.27nmol/l,p 0.05),whereas NO serum level lower(70.15±15.08umol/l Vs 79.35±17.10umol/l,p 0.05).The IGF-1 serum level highter in EH with LVH than in those without LVH(15.05±3.73nmol/l Vs 10.97±4.01nmol/l,p 0.01),while NO serum level were lower in EH with LVH than in those without LVH(55.80±15.35umol/l Vs 69.38±17.87umol/l,p 0.05).Conclusion These data indicate that serum IGF-1levels are increased in essential hypertension,with serum NO levels decreased,especially in EH with LVH.