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2000•Journa of Henan Medical UniversityRequires access

Deletion of p53 in Wilms' tumor

Weixing Zhang

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Abstract

Aim:To study p53 gene in 26 cases of sporadic Wilms'tumor. Methods:p53 gene was studied by Southern bolt hybridization with p53 cDNA probe.Results:One case with intragenic deletions of p53 gene was histologically classified as stroma predominated Wilms' tumor. Conclusion:The etiology of Wilms' tumor is complex, and the deletion of p53 gene may be correlated with the anaplasia of Wilms' tumor.

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Aim:To study p53 gene in 26 cases of sporadic Wilms'tumor. Methods:p53 gene was studied by Southern bolt hybridization with p53 cDNA probe.Results:One case with intragenic deletions of p53 gene was histologically classified as stroma predominated Wilms' tumor. Conclusion:The etiology of Wilms' tumor is complex, and the deletion of p53 gene may be correlated with the anaplasia of Wilms' tumor.

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Available abstract

Aim:To study p53 gene in 26 cases of sporadic Wilms'tumor. Methods:p53 gene was studied by Southern bolt hybridization with p53 cDNA probe.Results:One case with intragenic deletions of p53 gene was histologically classified as stroma predominated Wilms' tumor. Conclusion:The etiology of Wilms' tumor is complex, and the deletion of p53 gene may be correlated with the anaplasia of Wilms' tumor.

Key concepts: Anaplasia, Wilms' tumor, Gene, Biology, Complementary DNA, Tumor suppressor gene, Wilms tumour, Cancer research

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